Bo's BBQ. I'm sure there's better BBQ somewhere in San Francisco proper, but I don't know where.
They say that the Grgich Hills merlot goes particularly well with the short-end ribs, made from Niman Ranch pork. And the pecan pie is made with organic pecans and real Karo.
You know, it's a tribute to our endocrine systems that any of us East African Plains Apes can eat pecan pie without profound metabolic distress.